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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

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Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
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Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
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Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
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Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
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Related Experiment Video

Updated: May 1, 2026

Safety Precautions and Operating Procedures in an ABSL-4 Laboratory: 3. Aerobiology
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Pathogen safety of Beriate®.

Albrecht Gröner1

  • 1CSL Behring GmbH, Marburg, Germany.

Thrombosis Research
|April 15, 2014
PubMed
Summary

Beriate(®) plasma-derived factor VIII concentrate ensures safety through rigorous donor screening, viral inactivation, and removal steps. This approach has maintained an excellent safety record with no proven virus transmissions over 20 years.

Area of Science:

  • Hematology
  • Virology
  • Biotechnology

Background:

  • Plasma-derived factor VIII (FVIII) concentrates are crucial for treating hemophilia A.
  • Ensuring pathogen safety in these concentrates is paramount for patient well-being.

Purpose of the Study:

  • To detail the comprehensive safety measures implemented in the manufacturing of Beriate(®), a plasma-derived FVIII concentrate.
  • To highlight the effectiveness of these measures in preventing pathogen transmission.

Main Methods:

  • Rigorous donor selection and screening for various viral markers (HBsAg, HIV-1/2, HCV, HAV, HBV, HCV, B19V).
  • Implementation of dedicated virus reduction steps, including pasteurization and 19 nm virus filtration.
  • Validation studies using diverse viruses and prion preparations to confirm process efficacy.
Keywords:
Beriate(®)Haemophilia APasteurizationPathogen safetyPlasma-derived productVirus filtration

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Main Results:

  • Demonstrated effective inactivation of enveloped and non-enveloped viruses.
  • Effective removal of viruses and prions larger than 19 nm.
  • An excellent safety record over 20 years of clinical use with no documented virus transmissions.

Conclusions:

  • The multi-layered safety strategy for Beriate(®) ensures high pathogen safety.
  • Continuous improvement of safety measures maintains and enhances the product's excellent safety profile.
  • Beriate(®) offers a safe and effective treatment option for hemophilia A.