Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What are Viruses?00:50

What are Viruses?

128.1K
Overview
128.1K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

10.8K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K
Diversity of Archaea I01:30

Diversity of Archaea I

627
Archaea, a domain of single-celled microorganisms, are classified into five major phyla based on genetic and biochemical characteristics: Euryarchaeota, Crenarchaeota, Thaumarchaeota, Korarchaeota, and Nanoarchaeota. Among these, the phylum Euryarchaeota is notable for its remarkable diversity in morphology, metabolism, and ecological adaptations.Morphological and Metabolic DiversityMembers of Euryarchaeota exhibit a variety of cellular shapes, including rods and cocci. Their metabolic pathways...
627
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

107.2K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.2K
Cell Diversity01:13

Cell Diversity

5.1K
The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular...
5.1K
Diversity of Archaea II01:24

Diversity of Archaea II

521
Archaea, one of the three domains of life, exhibit remarkable diversity and adaptability, thriving in both extreme and moderate environments. Historically, most identified archaea have been classified into two major phyla: Euryarchaeota and Crenarchaeota. However, recent molecular studies have expanded this classification to include three additional phyla: Thaumarchaeota, Nanoarchaeota, and Korarchaeota, each exhibiting unique characteristics and ecological roles.Thaumarchaeota: Mesophiles...
521

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short Report: Update on CCHFV Seroprevalence in Mauritanian Camels and Cattle Sampled Between 2020 and 2021.

Tropical medicine & international health : TM & IH·2026
Same author

Sero-epidemiology of Crimean-Congo haemorrhagic fever in mixed crop-livestock farming households in Burkina Faso: a one health study.

PloS one·2026
Same author

Relevance of potential endocytosis motifs in Cedar virus glycoprotein G for its biological activity.

Journal of virology·2026
Same author

Pathogen screening of Zambian ticks: new insights on the occurrence of tick-borne pathogens in the country.

Parasites & vectors·2026
Same author

First Detection of Usutu Virus in Harbor Seals (<i>Phoca vitulina</i>).

Viruses·2026
Same author

Case Report: Two cases of mammary intraductal papillary adenomas in nulliparous aged dairy cattle.

Frontiers in veterinary science·2026

Related Experiment Video

Updated: Jan 31, 2026

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.9K

Different Outcomes of Experimental Hepatitis E Virus Infection in Diverse Mouse Strains, Wistar Rats, and Rabbits.

Josephine Schlosser1, Lisa Dähnert2, Paul Dremsek3

  • 1Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany. josephine.schlosser@gmx.de.

Viruses
|December 23, 2018
PubMed
Summary

Rabbits, not mice, show susceptibility to Hepatitis E virus genotype 3 (HEV-3) infection, offering a new model for studying zoonotic HEV-3. This rabbit model aids in evaluating potential vaccines against HEV-3.

Keywords:
BALB/cC57BL/6Hepatitis E virusanimal modelgenotype 3knockout mousemouserabbitratwild boar

More Related Videos

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.7K
Influenza A Virus Studies in a Mouse Model of Infection
10:44

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

29.8K

Related Experiment Videos

Last Updated: Jan 31, 2026

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.9K
A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.7K
Influenza A Virus Studies in a Mouse Model of Infection
10:44

Influenza A Virus Studies in a Mouse Model of Infection

Published on: September 7, 2017

29.8K

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Hepatitis E virus genotype 3 (HEV-3) causes zoonotic infections in industrialized countries.
  • Existing animal models for HEV-3, like swine, are large, and a suitable small animal model is lacking.
  • Natural HEV infections have not been demonstrated in mice.

Purpose of the Study:

  • To evaluate the susceptibility of different mouse strains, rats, and rabbits to HEV-3 infection.
  • To assess virus replication, shedding, and immune responses in experimentally infected animals.
  • To determine the potential of rabbits as a model for HEV-3 infection and vaccine studies.

Main Methods:

  • Experimental inoculation of C57BL/6 mice (wild-type, IFNAR-/- , CD4-/- , CD8-/- ), BALB/c nude mice, Wistar rats, and European rabbits with a wild boar-derived HEV-3 strain.
  • Monitoring of virus replication (HEV RNA) and shedding.
  • Detection of humoral immune responses (anti-HEV antibodies).
  • Evaluation of immunosuppressive dexamethasone treatment in rats.
  • Assessment of protection against HEV-3 challenge in rabbits immunized with recombinant HEV-3 and ratHEV capsid proteins.

Main Results:

  • HEV RNA and anti-HEV antibodies were detected in some rats and all rabbits, but not in any mouse strains.
  • Immunosuppressive dexamethasone treatment did not increase HEV susceptibility in rats.
  • Immunization of rabbits with recombinant HEV-3 and ratHEV capsid proteins conferred protection against HEV-3 challenge.

Conclusions:

  • Mice are not suitable models for HEV-3 infection.
  • Rabbits are susceptible to HEV-3 and can serve as a valuable alternative to non-human primate and swine models.
  • The rabbit model provides a basis for evaluating HEV-3 vaccines.