Related Experiment Video
Updated: May 1, 2026

2D and 3D Matrices to Study Linear Invadosome Formation and Activity
Published on: June 2, 2017
Coupling between acto-adhesive machinery and ECM degradation in invadosomes
Olivier Destaing1, Christos Petropoulos1, Corinne Albiges-Rizo1
1Institut Albert Bonniot; Université Joseph Fourier; Grenoble, France.
Abstract:
Invadosomes have two main functions represented by their actin-rich and adhesive components and their polarized secretory pathways controlling the delivery of metalloproteases necessary to degrade extracellular matrix (ECM). Invadosomes include invadopodia and podosomes, which have subtle differences in molecular composition, dynamics, and structure. These differences could reflect different stages of invadosome maturation. This review will outline current knowledge on the coupling between the acto-adhesive machinery and the ECM degradation activity in invadosome diversity. Multiple works support that these two functions are not automatically linked but seem to be finely regulated to allow different functions of invadosomes. We will explore the paradigmatic aspect of invadosomes, which are able to interact with ECM to degrade it so as to better control their own dynamics. Understanding the fine-tuning between these two functions could serve to understand the link between the different types of invadosomes from invadopodia to podosomes.
Related Concept Videos
Cancer Cell Migration through Invadopodia
Activation of Integrins
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
Anchoring Junctions
Intracellular Signaling Affects Focal Adhesions
Some...
Tension Response at Adherens Junctions
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...

