Vitamin D and diabetes mellitus: an update 2013
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Published on: December 9, 2015
Luiz Henrique Maciel Griz1, Francisco Bandeira1, Mônica Andrade Lima Gabbay2
1Endocrinology, Diabetes and Bone Diseases Division of Agamenon Magalhães Hospital, Universidade Federal de Pernambuco, Recife, PE, Brazil.
Abstract:
Vitamin D deficiency and diabetes mellitus are two common conditions and they are widely prevalent across all ages, races, geographical regions, and socioeconomic conditions. Epidemiologic studies have shown association of vitamin D deficiency and increased risk of chronic diseases, such as cancer, cardiovascular disease, type 2 diabetes, and autoimmune diseases, such as multiple sclerosis and type 1 diabetes mellitus. The identification of 1,25(OH)2D receptors and 1-α-hydroxilase expression in pancreatic beta cells, in cells of the immune system, and in various others tissues, besides the bone system support the role of vitamin D in the pathogenesis of type 2 diabetes. Observational studies have revealed an association between 25(OH) D deficiency and the prevalence of type 1 diabetes in children and adolescents. This review will focus on the concept of vitamin D deficiency, its prevalence, and its role in the pathogenesis and risk of diabetes mellitus and cardiovascular diseases.
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