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Related Concept Videos

Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

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Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
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Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

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Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...
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Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

5.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.1K
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

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Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
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Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

26
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor,...
26

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Related Experiment Video

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Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
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Thyroid function and body weight: a community-based longitudinal study.

Lena Bjergved1, Torben Jørgensen2, Hans Perrild3

  • 1Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup, Denmark; Department of Endocrinology, Bispebjerg University Hospital, Copenhagen, Denmark.

Plos One
|April 15, 2014
PubMed
Summary
This summary is machine-generated.

Thyroid-stimulating hormone (TSH) levels did not predict future weight changes, nor did body mass index (BMI) predict TSH changes. However, changes in TSH and weight were linked over 11 years in adults.

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Area of Science:

  • Endocrinology
  • Metabolic Health
  • Population Health

Background:

  • Body weight is linked to overt thyroid dysfunction.
  • Thyroid hormone levels within the normal range may correlate with body weight, but longitudinal data is limited.
  • The relationship between serum thyrotropin (TSH) and body weight over time requires further investigation.

Purpose of the Study:

  • To examine the longitudinal association between serum thyrotropin (TSH) and body weight in a general adult population.
  • To determine if baseline TSH predicts future weight changes.
  • To assess if baseline body mass index (BMI) predicts future TSH changes.

Main Methods:

  • A random sample of 2,102 adults (aged 18-65) from the DanThyr study with 11-year follow-up data.
  • Exclusion of individuals with current or past thyroid disease treatment.
  • Analysis using multiple linear regression, stratified by sex and adjusted for age, smoking, and physical activity.

Main Results:

  • Baseline TSH was not associated with changes in weight for either sex.
  • Baseline BMI was not associated with changes in TSH for either sex.
  • A significant association was found between changes in serum TSH and changes in weight: a TSH increase correlated with weight gain in both men and women.

Conclusions:

  • Serum TSH levels do not determine future weight changes, and BMI does not determine future TSH changes.
  • An association exists between concurrent changes in weight and TSH levels.
  • This suggests a dynamic interplay between thyroid function and body weight over time.