Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.2K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clocks and Dominoes: Timing Mechanisms of Embryogenesis.

bioRxiv : the preprint server for biology·2026
Same author

Systematic review on biomarker potential of vitreous microRNA in retinal disease.

Frontiers in ophthalmology·2025
Same author

EmbryoProfiler: A Visual Clinical Decision Support System for IVF.

IEEE transactions on visualization and computer graphics·2025
Same author

Rapamycin rescues APC-mutated colon organoid differentiation.

Cancer gene therapy·2025
Same author

Predicting colorectal cancer risk in FAP patients using patient-specific organoids.

Cancer gene therapy·2025
Same author

Second-harmonic generation microscopy of murine scleral remodeling by collagenase and reparative collagen mimetic peptides.

Frontiers in medicine·2025

Related Experiment Video

Updated: May 1, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

9.3K

Modeling neurodevelopmental disorders using human pluripotent stem cells.

Michael Telias1, Dalit Ben-Yosef

  • 1The Wolfe PGD-Stem Cell Lab, Racine IVF Unit, Lis Maternity Hospital, Tel-Aviv Sourasky Medical Center, Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Stem Cell Reviews and Reports
|April 15, 2014
PubMed
Summary

Human pluripotent stem cells (hPSCs) offer a promising in vitro model for studying neurodevelopmental disorders (NDs). This review highlights their use in understanding impaired neurogenesis and synaptogenesis, crucial for intellectual disability research.

More Related Videos

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
06:38

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

1.1K
Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
07:40

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Published on: April 14, 2017

20.2K

Related Experiment Videos

Last Updated: May 1, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

9.3K
In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
06:38

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

1.1K
Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
07:40

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Published on: April 14, 2017

20.2K

Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Developmental Biology

Background:

  • Neurodevelopmental disorders (NDs) significantly impact brain development.
  • Existing animal and cellular models have limitations in replicating human phenotypes.
  • Human pluripotent stem cells (hPSCs) present a valuable alternative for studying NDs.

Purpose of the Study:

  • To review recent studies utilizing hPSCs for modeling NDs.
  • To analyze methodologies and results of hPSC-derived neural models.
  • To assess the potential of hPSCs as pre-clinical research and drug screening platforms.

Main Methods:

  • Literature review of studies using hPSCs for ND research.
  • Analysis of in vitro neural differentiation, gene expression, and neuronal profiling.
  • Focus on studies incorporating electrophysiological recordings for validation.

Main Results:

  • hPSCs enable the study of impaired neurogenesis and synaptogenesis.
  • Electrophysiological data are crucial for validating neuronal fate and disease phenotypes.
  • hPSC-derived neurons offer insights into intellectual disability and delayed neurodevelopment.

Conclusions:

  • hPSCs are a powerful tool for in vitro modeling of neurodevelopmental disorders.
  • Electrophysiological validation is essential for robust disease modeling.
  • hPSC-based models are critical for advancing human pre-clinical research and drug discovery for NDs.