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Related Experiment Video

Updated: May 1, 2026

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

Integrating in vitro organ-specific function with the microcirculation.

Monica L Moya¹, Steven C George²

¹Department of Biomedical Engineering, University of California, Irvine, California ; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, California.

Current Opinion in Chemical Engineering

|April 15, 2014

Summary

This summary is machine-generated.

Researchers are developing 3D microphysiological systems to better model human organ function for drug testing and regenerative medicine. These advanced models incorporate microcirculation, crucial for mimicking organ-specific physiology beyond animal or 2D models.

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Development and Characterization of In Vitro Microvessel Network and Quantitative Measurements of Endothelial [Ca2+]i and Nitric Oxide Production

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Published on: May 19, 2016

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Related Experiment Videos

Last Updated: May 1, 2026

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

Development and Characterization of In Vitro Microvessel Network and Quantitative Measurements of Endothelial [Ca2+]i and Nitric Oxide Production

Development and Characterization of In Vitro Microvessel Network and Quantitative Measurements of Endothelial [Ca2+]i and Nitric Oxide Production

Published on: May 19, 2016

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Area of Science:

Biomedical Engineering
Regenerative Medicine
Pharmacology

Background:

Current animal models and 2D cell cultures inadequately replicate human physiology for drug response prediction.
Microcirculation is vital for nutrient/waste transport and organ-specific functions.
Tissue engineering aims to create functional 3D human organ models.

Purpose of the Study:

Review progress in creating in vitro functional microvessel networks.
Emphasize organ-specific characteristics for future microphysiological systems.
Focus on lung, brain, liver, and muscle (skeletal, cardiac) organ systems.

Main Methods:

Literature review of advancements in microvessel network creation.
Analysis of organ-specific physiological requirements for in vitro models.
Identification of key structural and functional features for biomimicry.

Main Results:

Significant progress has been made in developing in vitro microvessel networks.
Organ-specific considerations are crucial for accurate physiological mimicry.
The review highlights challenges and opportunities in replicating complex organ functions.

Conclusions:

3D microphysiological systems with functional microcirculation are essential for accurate human physiology modeling.
Future research should focus on integrating organ-specific microvascular features into these systems.
These advanced models hold promise for improved drug development and therapeutic strategies.