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Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
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Upconversion nanoparticles in bioassays, optical imaging and therapy.

Phuong-Diem Nguyen, Sang Jun Son, Junhong Min

    Journal of Nanoscience and Nanotechnology
    |April 16, 2014
    PubMed
    Summary

    Rare-earth doped nanoparticles (UCNPs) offer superior luminescence for bioassays and imaging. These upconversion nanoparticles show promise in biomedical science for diagnostics and therapy.

    Area of Science:

    • Nanotechnology
    • Biomedical Science
    • Materials Science

    Background:

    • Upconversion nanoparticles (UCNPs) are a novel class of phosphorescent materials.
    • UCNPs exhibit unique optical properties, serving as alternatives to traditional fluorescence techniques.
    • Their development has spanned decades, with increasing applications in biological fields.

    Purpose of the Study:

    • To review recent advancements in UCNP applications within bioassays, optical imaging, and therapy.
    • To highlight the potential of UCNPs in biomedical science.
    • To discuss current challenges and future prospects of UCNP-based detection.

    Main Methods:

    • Literature review of UCNP research in biological and biomedical applications.
    • Analysis of UCNP properties relevant to bio-imaging and diagnostics.

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  • Discussion of UCNP conjugation with biomolecules for various platforms.

    • Main Results:

    • UCNPs demonstrate excellent biocompatibility and suitable size for biological conjugation.
    • Key optical properties include high luminescence, deep tissue penetration, low background, and photostability.
    • UCNPs are effective as contrast agents in both in vitro and in vivo settings.

    Conclusions:

    • UCNPs present significant potential for advancing biomedical science.
    • Further research is needed to overcome challenges in UCNP-based detection and therapeutic modalities.
    • UCNPs are poised to enhance bioassays, optical imaging, and therapeutic strategies.