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Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
Doxorubicin nanoconjugates
Abstract:
Doxorubicin is one of the most widely administered drugs for treatment of cancer. The shortcomings commonly encountered with this drug are severe cardiotoxicity, narrow therapeutic indices, and the development of multiple drug resistance. Hence, several nanoparticulate drug delivery systems have been designed to overcome these limitations and to improvise the overall therapeutic efficacy of doxorubicin. This review outlines the doxorubicin delivery systems, viz., metals and metal oxide nanoparticles, carbon nanotubes, liposomes, nanoparticles of solid lipid materials, lipid microemulsions, polymer-based nanoparticles, protein-attached nanoparticles, polysaccharide nanoparticles, functional polymers, and nanoparticles of virus.
Insights
Doxorubicin, a common cancer drug, faces challenges like toxicity and resistance. Nanoparticulate drug delivery systems offer promising solutions to improve its effectiveness and safety in cancer treatment.
Area of Science:
- Oncology
- Nanomedicine
- Drug Delivery Systems
Background:
- Doxorubicin is a widely used chemotherapy agent for various cancers.
- Significant limitations include cardiotoxicity, narrow therapeutic index, and multidrug resistance.
- These challenges necessitate innovative approaches to enhance doxorubicin's therapeutic profile.
Purpose of the Study:
- To review various nanoparticulate drug delivery systems for doxorubicin.
- To highlight systems designed to overcome doxorubicin's limitations.
- To assess improvements in therapeutic efficacy and safety.
Main Methods:
- Comprehensive literature review of nanoparticulate doxorubicin delivery systems.
- Categorization of delivery systems based on material composition.
- Analysis of reported advantages and disadvantages of each system.
Main Results:
- Diverse nanoparticulate systems show potential in overcoming doxorubicin's limitations.
- Systems include metal/metal oxide nanoparticles, carbon nanotubes, liposomes, and polymeric nanoparticles.
- Lipid-based nanoparticles, protein/polysaccharide nanoparticles, and viral nanoparticles are also discussed.
Conclusions:
- Nanoparticulate drug delivery significantly enhances doxorubicin's therapeutic efficacy.
- These systems offer a promising strategy to mitigate cardiotoxicity and drug resistance.
- Further research into optimized nanoparticle formulations is warranted for improved cancer therapy.
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