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Related Experiment Video

Updated: May 1, 2026

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
09:09

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

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Doxorubicin nanoconjugates.

Kannan Deepa, Siddhartha Singha, Tapobrata Panda

    Journal of Nanoscience and Nanotechnology
    |April 16, 2014
    PubMed
    Summary

    Doxorubicin, a common cancer drug, faces challenges like toxicity and resistance. Nanoparticulate drug delivery systems offer promising solutions to improve its effectiveness and safety in cancer treatment.

    Area of Science:

    • Oncology
    • Nanomedicine
    • Drug Delivery Systems

    Background:

    • Doxorubicin is a widely used chemotherapy agent for various cancers.
    • Significant limitations include cardiotoxicity, narrow therapeutic index, and multidrug resistance.
    • These challenges necessitate innovative approaches to enhance doxorubicin's therapeutic profile.

    Purpose of the Study:

    • To review various nanoparticulate drug delivery systems for doxorubicin.
    • To highlight systems designed to overcome doxorubicin's limitations.
    • To assess improvements in therapeutic efficacy and safety.

    Main Methods:

    • Comprehensive literature review of nanoparticulate doxorubicin delivery systems.
    • Categorization of delivery systems based on material composition.

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    Related Experiment Videos

    Last Updated: May 1, 2026

    Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
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    Published on: June 23, 2020

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    Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
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    Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
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    Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

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  • Analysis of reported advantages and disadvantages of each system.

    • Main Results:

    • Diverse nanoparticulate systems show potential in overcoming doxorubicin's limitations.
    • Systems include metal/metal oxide nanoparticles, carbon nanotubes, liposomes, and polymeric nanoparticles.
    • Lipid-based nanoparticles, protein/polysaccharide nanoparticles, and viral nanoparticles are also discussed.

    Conclusions:

    • Nanoparticulate drug delivery significantly enhances doxorubicin's therapeutic efficacy.
    • These systems offer a promising strategy to mitigate cardiotoxicity and drug resistance.
    • Further research into optimized nanoparticle formulations is warranted for improved cancer therapy.