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Antibiotic releasing biodegradable scaffolds for osteomyelitis
1Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Science & Research Center, Amrita Vishwa Vidyapeetham University, Cochin, Kerala 682041, India. manithanair@aims.amrita.edu.
Current Drug Delivery
|April 16, 2014
Summary
Biodegradable carriers offer a solution for chronic osteomyelitis treatment, releasing antibiotics locally and supporting bone regeneration. This avoids repeat surgeries needed for non-biodegradable polymethylmethacrylate (PMMA) implants.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Infectious Diseases
Background:
- Osteomyelitis involves progressive, inflammatory bone degeneration.
- Current treatments for chronic osteomyelitis require infected bone removal and local antibiotic delivery.
- Polymethylmethacrylate (PMMA) is a common, non-biodegradable carrier, necessitating a second surgery for removal.
Purpose of the Study:
- To review biodegradable carrier systems for osteomyelitis treatment.
- To highlight alternatives to non-biodegradable PMMA carriers.
- To discuss systems supporting antibiotic release and bone regeneration.
Main Methods:
- Literature review of biodegradable carrier systems for osteomyelitis.
- Analysis of systems for local antibiotic delivery.
- Evaluation of carriers supporting debrided bone formation.
Main Results:
- Various biodegradable materials have been investigated as antibiotic carriers.
- These systems offer sustained local antibiotic release.
- Some biodegradable carriers also promote new bone formation.
Conclusions:
- Biodegradable carriers represent a promising advancement in osteomyelitis management.
- They eliminate the need for secondary removal surgeries.
- These systems can improve patient outcomes by combining infection control with bone repair.
