Related Experiment Video
Updated: May 1, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Particle Based Simulation of the Aortic Valve by Considering Heart's Pulsation
Nobuhiko Mukai1, Yusuke Abe1, Youngha Chang2
1Gradute School of Engineering, Tokyo City Univeristy, Japan.
Abstract:
We have performed a dynamic simulation of the aortic valve by considering heart's pulsation. In the simulation, there are two different types of materials: elastic body for the aortic wall and the aortic valve, and fluid for blood. In order to calculate the collision detection between two different types of materials, we have used a particle method. In addition, the pressure difference between the left ventricle and the aorta causes the blood flow in the inside of the aorta. Then, the pressure change is given as the parameter of the simulation by referring to the typical pattern of the heart's pulsation. Finally, we have succeeded in performing the simulation on opening and closing of the aortic valve, and have also visualized the pressure in the inside of the aorta and the stress distribution on the aortic valve.
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