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Updated: May 1, 2026

Water in Oil Emulsions: A New System for Assembling Water-soluble Chlorophyll-binding Proteins with Hydrophobic Pigments
Published on: March 21, 2016
Synthesis of the first water-soluble hemicryptophane host: selective recognition of choline in aqueous medium
Aline Schmitt1, Vincent Robert, Jean-Pierre Dutasta
1Laboratoire de Chimie, École Normale Supérieure de Lyon , CNRS, UCBL, 46, Allée d'Italie, F-69364 Lyon, France.
Abstract:
The first water-soluble hemicryptophane cage compound, 4, was synthesized in seven steps from commercially available products, and its complexation properties were studied. NMR and ITC experiments indicate that 4 is an efficient receptor for choline in water (ΔG° = -5.2 kcal mol(-1)). High substrate selectivity was achieved since no complexation was observed for its closely related substrates: glycine betaine and betaine aldehyde. Density functional theory calculations were performed to analyze the interactions that are involved in the formation of the inclusion complex.
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