Related Experiment Video
Updated: Aug 12, 2026
Isolation of Cells with Morphological and Spatial Information from Oral Submucous Fibrosis Samples by Laser Capture Microdissection
Published on: August 11, 2023
[Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population]
Yinu Ma1, Tingyu Xie1, Guowei Zhu1
1Department of Ophthalmology, the First Affiliated Hospital of Xinjiang Medical University,Xinjiang 830054, China.
Objective:
In this study, we evaluate the association profiles of the lysyl oxidase-like 1 ( LOXL1) gene polymorphisms with exfoliation syndrome in XFS Uygur population.
Methods:
Case-control study. Sixty-four unrelated Uygur patients with XFS (including 7 patients with Exfoliation Syndrome Glaucoma) and 127 Uygur control subjects were included. All of control subjects were selected from the same area, passed through the same ophthalmic checks and confirmed without any expressions of XFS. Most of them suffered from cataract and other ophthalmic disease.Genotypes of the three single nucleotide polymorphisms (SNPs) of LOXL1 (rs1048661, rs2165241 and rs3825942) were analyzed by direct sequencing following PCR amplification, and a case-control association study was performed and judged by odd ratio (OR) with (95% confidential interval).
Results:
G allele of rs1048661 [OR:1.92 (1.14-3.22)], G of rs3825942 [OR:4.86 (2.02-11.68)], and T of rs2165241[OR:3.98 (2.54-6.25)] were risk alleles for the disorder. The genotypes TT for rs2165241 [OR:2.20 (1.04-4.65)] were risk genotypes for the disease.
Conclusion:
LOXL1 is a susceptibility gene of XFS in the Uygur populations. The risk alleles of rs1048661, rs3825942 and rs2165241 in Uygur subjects were identified to be significantly associated with XFS individually.
