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Vitamin D levels and menopause-related symptoms
Erin S LeBlanc1, Manisha Desai, Nancy Perrin
1From the 1Center for Health Research, Kaiser Permanente Northwest, Portland, OR; 2Quantitative Sciences Unit, Department of Medicine, Stanford University School of Medicine, Stanford, CA; 3University of Buffalo, Buffalo, NY; 4Brigham and Women's Hospital, Harvard Medical School, Boston, MA; 5Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA; 6Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PA; 7Department of Medicine, Stanford University School of Medicine, Stanford, CA; 8University of Tennessee Health Science Center, Memphis, TN; 9Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA; 10Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN; 11University of Miami, Miami, FL; 12Biobehavioral Nursing, University of Washington, Seattle, WA; and 13Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA.
Objective:
This study aims to determine whether vitamin D levels are associated with menopause-related symptoms in older women.
Methods:
A randomly selected subset of 1,407 women, among 26,104 potentially eligible participants of the Women's Health Initiative Calcium and Vitamin D trial of postmenopausal women aged 51 to 80 years, had 25-hydroxyvitamin D [25(OH)D] levels measured at the Women's Health Initiative Calcium and Vitamin D trial baseline visit. Information about menopause-related symptoms at baseline was obtained by questionnaire and included overall number of symptoms and composite measures of sleep disturbance, emotional well-being, and energy/fatigue, as well as individual symptoms. After exclusions for missing data, 530 women (mean [SD] age, 66.2 [6.8] y) were included in these analyses.
Results:
Borderline significant associations between 25(OH)D levels and total number of menopausal symptoms were observed (with P values ranging from 0.05 to 0.06 for fully adjusted models); however, the effect was clinically insignificant and disappeared with correction for multiple testing. No associations between 25(OH)D levels and composite measures of sleep disturbance, emotional well-being, or energy/fatigue were observed (P's > 0.10 for fully adjusted models).
Conclusions:
There is no evidence for a clinically important association between serum 25(OH)D levels and menopause-related symptoms in postmenopausal women.
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