A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy
Hui He1, Pui-Chi Lo, Dennis K P Ng
1Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong (P. R. China), Fax: (+852) 2603 5057.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|April 17, 2014
Abstract:
A zinc(II) phthalocyanine substituted with a 2,4-dinitrobenzenesulfonate group has been prepared. Its fluorescence emission and reactive oxygen species generation can be greatly enhanced by glutathione in phosphate-buffered saline and inside MCF-7 cells. This compound thus functions as a highly efficient molecular-based activatable photosensitizer.


