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Lubricin: a novel means to decrease bacterial adhesion and proliferation.

George E Aninwene1, Pegah N Abadian, Vishnu Ravi

  • 1Department of Chemical Engineering, Northeastern University, Boston, Massachusetts, 02115.

Journal of Biomedical Materials Research. Part A
|April 17, 2014
PubMed
Summary
This summary is machine-generated.

Lubricin (LUB) significantly reduces Staphylococcus aureus attachment and growth on surfaces, offering potential benefits for medical implants. This study demonstrates LUB

Keywords:
Staphylococcus aureusStaphylococcus epidermidisbacterial adhesionbiofoulingimplantinfectionkinetic bacterial growth modelinglubricinprotein coating

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Area of Science:

  • Biomaterials Science
  • Microbiology
  • Surface Chemistry

Background:

  • Bacterial adhesion and proliferation on medical implants can lead to biofilm formation and infections.
  • Lubricin (LUB) is a glycoprotein known for its lubricating properties, with potential anti-adhesion capabilities.
  • Vitronectin (VTN) and bovine submaxillary mucin share structural similarities with LUB and were investigated for comparison.

Purpose of the Study:

  • To investigate the efficacy of lubricin (LUB) in preventing bacterial attachment and proliferation on model polystyrene surfaces.
  • To compare the anti-adhesion properties of LUB with vitronectin (VTN) and bovine submaxillary mucin.
  • To assess the potential of LUB in reducing initial bacterial adhesion and suppressing biofilm formation.

Main Methods:

  • Experiments were conducted on model tissue culture polystyrene surfaces.
  • Bacterial attachment and proliferation of Staphylococcus aureus and Staphylococcus epidermidis were measured over 24 hours.
  • Phosphate-buffered saline (PBS)-soaked surfaces served as controls.
  • The effect of LUB, VTN, and mucin on bacterial lag time was evaluated.

Main Results:

  • LUB reduced Staphylococcus aureus attachment and growth by approximately 13.9% and increased lag time by 27% compared to PBS controls.
  • VTN reduced S. aureus adhesion and growth by approximately 11% and increased lag time by 43%.
  • Mucin coatings showed less substantial reduction in S. aureus and Staphylococcus epidermidis proliferation compared to LUB.

Conclusions:

  • Lubricin (LUB) is effective in reducing initial bacterial adhesion and proliferation of S. aureus and S. epidermidis on model surfaces.
  • These findings suggest LUB's potential utility in preventing biofilm formation on medical implants.
  • Further research is warranted to explore LUB's clinical applications for improved patient outcomes.