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The relationship between sleep disorders and testosterone.

Gary Wittert1

  • 1Discipline of Medicine and Freemasons Foundation Centre for Men's Health, University of Adelaide, Adelaide, South Australia, Australia.

Current Opinion in Endocrinology, Diabetes, and Obesity
|April 18, 2014
PubMed
Summary
This summary is machine-generated.

Serum testosterone influences sleep timing and circadian rhythms. While sleep deprivation lowers testosterone, treatment is unlikely to improve sleep in hypogonadal men, emphasizing underlying condition management.

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Area of Science:

  • Endocrinology
  • Sleep Medicine
  • Chronobiology

Background:

  • Sex steroids, including testosterone, significantly influence circadian rhythms and sleep physiology.
  • Testosterone plays a role in the organizational and activational effects on sleep patterns.

Purpose of the Study:

  • To review current understanding and recent data on the intricate relationship between serum testosterone levels and both normal and disordered sleep.
  • To explore how testosterone impacts sleep timing, circadian organization, and hormonal variations.

Main Methods:

  • Literature review of evolving concepts and recent scientific data.
  • Analysis of studies investigating testosterone's effects on sleep architecture and hormonal diurnal variations.
  • Examination of findings in various populations, including adolescents, elderly individuals, and those with obstructive sleep apnea (OSA).

Main Results:

  • Testosterone affects circadian rhythm organization and sleep timing, not duration; rising levels during puberty correlate with later bedtimes.
  • Diurnal testosterone variation is sleep-dependent. Total sleep deprivation reduces testosterone, with sleep restriction impacting levels primarily in the first half of the night.
  • In men with OSA, low testosterone is linked to obesity, improving with weight loss. Testosterone treatment may transiently worsen OSA severity but is not an absolute contraindication.

Conclusions:

  • Testosterone treatment is generally not recommended for improving sleep in men with secondary hypogonadism (e.g., due to obesity or depression).
  • Management should focus on addressing the underlying abnormalities causing hypogonadism and sleep disturbances.