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Dynamic kinetic resolution of dehydrocoronamic acid

David A Chaplin1, Martin E Fox, Sebastian H B Kroll

  • 1Chirotech Technology Centre, Dr Reddy's Laboratories EU Ltd., Unit 410 Cambridge Science Park, Milton Road, Cambridge, CB4 0PE, UK. mfox@drreddys.com.

Chemical Communications (Cambridge, England)
|April 18, 2014
PubMed
Summary

Dehydrocoronamic acid racemization is achieved via N-acyl dehydration to azlactones. This process, combined with enzymatic resolution, enables dynamic kinetic resolution for enantiomer production.

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