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Related Experiment Video

Updated: May 1, 2026

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

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Published on: August 18, 2014

Cocaine- and amphetamine-regulated transcript peptide (CARTp): distribution and function in rat urinary bladder.

K Zvarova¹, G M Herrera, V May

¹Physiology Department, Slovak Health University, Bratislava, Slovak Republic.

Journal of Molecular Neuroscience : MN

|April 18, 2014

Summary

This summary is machine-generated.

Cocaine- and amphetamine-regulated transcript peptide (CARTp) is highly present in rat bladders and enhances detrusor and smooth muscle contractions. CARTp

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Area of Science:

Urology
Neuroscience
Endocrinology

Background:

The role of CARTp(55-102) in lower urinary tract function is not well understood.
CARTp is a peptide with known roles in regulating various physiological processes.

Purpose of the Study:

To investigate the distribution of CARTp(55-102) in the rat lower urinary tract.
To evaluate the effect of CARTp on urinary bladder function in vitro.

Main Methods:

Immunohistochemistry was used to determine CARTp distribution.
An isolated tissue bath system assessed the effects of CARTp on bladder strips.

Main Results:

CARTp(55-102) was found in neurons, nerve fibers, and nonneuronal endocrine cells in the rat urinary bladder.
CARTp significantly increased detrusor and spontaneous urinary bladder smooth muscle contractions.
CARTp's effects were dose-dependent and enhanced by the urothelium, independent of cholinergic, purinergic, or adrenergic pathways.

Conclusions:

CARTp(55-102) is widely expressed in the rat urinary bladder.
CARTp enhances bladder contractility, potentially by modulating urothelial signaling.
CARTp represents a potential target for modulating bladder function.