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Updated: May 1, 2026

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
Published on: January 19, 2019
Dynamic self-assembly of polycationic clusters based on cyclodextrins for pH-sensitive DNA nanocondensation and
Laura Gallego-Yerga1, M José González-Álvarez, Natalia Mayordomo
1Department of Organic Chemistry, Faculty of Chemistry, University of Sevilla, c/Profesor García González 1, 41011 Sevilla (Spain), Fax: (+34) 954624960.
Abstract:
The ability of cyclodextrin-based polycationic cluster to undergo reversible DNA condensation and release in a physiologically useful pH window has been finely tuned by the installation of a capping xylylene moiety at the secondary face of the cyclooligosaccharide. This strategy can be exploited advantageously in the design of self-assembling nonviral gene-delivery systems from molecular entities.

