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Updated: May 1, 2026
Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
Published on: December 24, 2016
Vaginal myeloid dendritic cells transmit founder HIV-1
Ruizhong Shen1, John C Kappes2, Lesley E Smythies3
1Department of Medicine (Gastroenterology), University of Alabama at Birmingham, Birmingham, Alabama, USA rshen@uab.edu pdsmith@uab.edu.
Abstract:
We report that primary human vaginal dendritic cells (DCs) display a myeloid phenotype and express CD4, CCR5, and CXCR4. Vaginal CD13(+) CD11c(+) DCs rapidly and efficiently bound transmitted/founder (T/F) CCR5-tropic (R5) viruses, transported them through explanted vaginal mucosa, and transmitted them in trans to vaginal and blood lymphocytes. Vaginal myeloid DCs may play a key role in capturing and disseminating T/F R5 HIV-1 in vivo and are candidate "gatekeeper" cells in HIV-1 transmission.
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