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Acute generalized exanthematous pustulosis induced by piroxicam: a case report

Y Cherif1, Moez Jallouli1, M Mseddi2

  • 1Department of Internal Medicine, Hedi Chaker University Hospital, Sfax, Tunisia.

Indian Journal of Pharmacology
|April 18, 2014
PubMed

Insights

Acute generalized exanthematous pustulosis (AGEP) is a severe skin reaction. Piroxicam, a non-steroid anti-inflammatory drug, rarely triggers AGEP, as seen in a case resolved by drug withdrawal.

Area of Science:

  • Dermatology
  • Pharmacovigilance

Background:

  • Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse drug reaction.
  • Commonly triggered by antibiotics like beta-lactams and macrolides.
  • Non-steroid anti-inflammatory drugs (NSAIDs) are rare triggers.

Observation:

  • A case of a woman presenting with generalized pustulosis after piroxicam use for renal colic.
  • Clinical and histological findings confirmed the diagnosis of AGEP.
  • Skin lesions resolved upon discontinuation of piroxicam.

Findings:

  • Piroxicam, an NSAID, can induce AGEP.
  • Early diagnosis and drug withdrawal are crucial for resolution.
  • Highlights the importance of considering NSAIDs in AGEP etiology.

Implications:

  • Expands the spectrum of known AGEP triggers.
  • Emphasizes the need for vigilance regarding NSAID-induced cutaneous reactions.
  • Informs clinical practice for managing severe drug-induced skin conditions.
Keywords:
Acute generalized exanthematous pustulosisadverse drug reactionspiroxicampustulosis

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