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Updated: May 1, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Central nervous system toxicities of chemotherapeutic agents
Parvin F Peddi1, Srinivas Peddi, Edgardo S Santos
1Division of Hematology Oncology, University of California, 10945 LeConte Avenue, Suite 2333, Los Angeles, CA 90095-7059, USA.
Abstract:
Although there has been a significant progress in the recognition and management of the most common chemotherapy side effects, there is limited data on CNS toxicities. Since CNS toxicities can cause significant morbidity and delay or interruption of potentially effective therapies, there is a need for better understanding, early detection, prompt discontinuation of the offending drug, and use of antidotes when available. This review describes neurological toxicities from some of the commonly used chemotherapy agents.
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