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Mast cell-restricted tetramer-forming tryptases and their beneficial roles in hemostasis and blood coagulation

Alicia Prieto-García1, Mariana C Castells2, Philip M Hansbro3

  • 1Allergy Service, Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Dr Esquerdo 46, Madrid 28007, Spain.

Immunology and Allergy Clinics of North America
|April 22, 2014
PubMed

Tetramer-forming tryptase (hTryptase-β) was recently discovered to have a prominent role in preventing the internal accumulation of life-threatening fibrin deposits and fibrin-platelet clots. The anticoagulant activity of hTryptase-β is an explanation for the presence of hemorrhagic disorders in some patients with anaphylaxis or mastocytosis. The fragments of hFibrinogen formed by the proteolysis of this prominent protein by hTryptase-β could be used as biomarkers in the blood and/or urine for the identification and monitoring of patients with mast cell-dependent disorders. Recombinant hTryptase-β has potential to be used in clinical settings where it is desirable to inhibit blood coagulation.

Keywords:
AnaphylaxisFibrin thrombin-dependent coagulationFibrinogenMast cellhTryptase-βmMCP-6mMCP-7

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