Advances in the Phenotyping and Management of Common Variable Immunodeficiency
Mikaela E Gill1, Aditi Jogdand1, Caroline Schissel2
1Clinical Immunodeficiency Program, Beth Israel Lahey Health, Division of Allergy & Immunology, Lahey Clinic, Burlington, MA, USA.
Abstract:
This article highlights advances in the phenotyping and management of common variable immunodeficiency (CVID). Advances in phenotyping include the use of cell-based, soluble, and genetic profiling, combined with novel applications like machine learning, to better define high-risk (complicated CVID) and low-risk (uncomplicated CVID) patient populations. Advances in management include first-in-class clinical trials to treat noninfectious disease manifestations based on convergent pathways of immune dysregulation in CVID.
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