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Updated: May 1, 2026
Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
Published on: May 27, 2015
Neuropsychological features of adult mastocytosis
Daniela S Moura1, Sophie Georgin-Lavialle2, Raphaël Gaillard3
1INSERM UMR 1163, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Paris, France; Paris Descartes - Sorbonne Paris Cité University, Imagine Institute, Paris, France; CNRS ERL 8254, Paris, France; Laboratory of Excellence GR-Ex, Paris, France; Service d'Hématologie clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Necker, Paris, France.
Abstract:
In approximately one-third of cases, patients with mastocytosis can display various disabling general and neuropsychological symptoms. General signs may have a major impact on quality of life. Neurologic symptoms are less frequent. In a majority of cases, the pathophysiology of these symptoms is not known but could be linked to tissular mast cell infiltration, mast cell mediator release, or both. Treatments aiming at reducing mast cell number and/or stabilizating mast cells may be useful. Preliminary results suggest that treatment with kinase inhibitors may improve symptoms of depression and cognitive impairment.
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