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The productive infection of alveolar macrophages by simian immunodeficiency virus
D J Ringler1, M S Wyand, D G Walsh
1Harvard Medical School, New England Regional Primate Research Center, Southborough, MA.
Journal of Medical Primatology
|January 1, 1989
Abstract:
Alveolar macrophages obtained from healthy rhesus monkeys were infected with SIV in vitro as documented by the appearance of reverse transcriptase activity in the cell-free supernatant, electronmicroscopy, and immunohistochemical methods detecting SIV-related core protein. The results demonstrate permissive infection of alveolar macrophages with SIV in vitro and define a system for studying macrophage-SIV interactions.