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Updated: May 1, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

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Modulation of tolerogenic dendritic cells and autoimmunity

Sun Jung Kim1, Betty Diamond1

  • 1The Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, United States.

Seminars in Cell & Developmental Biology
|April 22, 2014
PubMed

A key function of dendritic cells (DCs) is to induce either immune tolerance or immune activation. Many new DC subsets are being recognized, and it is now clear that each DC subset has a specialized function. For example, different DC subsets may express different cell surface molecules and respond differently to activation by secretion of a unique cytokine profile. Apart from intrinsic differences among DC subsets, various immune modulators in the microenvironment may influence DC function; inappropriate DC function is closely related to the development of immune disorders. The most exciting recent advance in DC biology is appreciation of human DC subsets. In this review, we discuss functionally different mouse and human DC subsets both in lymphoid organs and non-lymphoid organs, the molecules that regulate DC function, and the emerging understanding of the contribution of DCs to autoimmune diseases.

Keywords:
AutoimmunityDendritic cellsTissue-resident dendritic cellsTolerogenic dendritic cells

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