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Related Experiment Video

Updated: May 1, 2026

Assessing Functional Performance in the Mdx Mouse Model
10:32

Assessing Functional Performance in the Mdx Mouse Model

Published on: March 27, 2014

32.7K

Assessing functional performance in the mdx mouse model.

Annemieke Aartsma-Rus1, Maaike van Putten2

  • 1Department of Human Genetics, Leiden University Medical Center.

Journal of Visualized Experiments : Jove
|April 22, 2014
PubMed
Summary
This summary is machine-generated.

Functional tests in mice are crucial for Duchenne muscular dystrophy (DMD) research. This study details reliable methods for assessing muscle function in the mdx mouse model, aiding therapeutic development.

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Last Updated: May 1, 2026

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Area of Science:

  • Biomedical research
  • Animal models of disease
  • Neuromuscular disorders

Background:

  • Duchenne muscular dystrophy (DMD) is a severe genetic disorder with no cure.
  • Current research focuses on pharmaceutical and gene therapies progressing to clinical trials.
  • Assessing muscle function is key for evaluating treatment efficacy in DMD models.

Purpose of the Study:

  • To describe reliable and reproducible functional tests for preclinical assessment of muscle function in the mdx mouse model of DMD.
  • To provide standardized operating procedures for common functional tests.
  • To facilitate data comparison across laboratories in DMD research.

Main Methods:

  • Detailed protocols for noninvasive tests: forelimb grip strength, wire hanging, grid hanging, and rotarod running.
  • Description of forced treadmill running for disease enhancement or protective effect assessment.
  • Emphasis on standard operating procedures for reproducibility.

Main Results:

  • Established protocols for commonly used functional tests in the mdx mouse model.
  • Demonstrated methods for reliable and reproducible assessment of muscle function, strength, condition, and coordination.
  • Provided a framework for consistent data collection in DMD preclinical studies.

Conclusions:

  • Standardized functional tests are essential for robust preclinical evaluation of DMD therapies.
  • Reproducible methods enable accurate assessment of disease progression and therapeutic intervention effects.
  • These protocols will aid in comparing data and advancing DMD research globally.