Related Experiment Video
Updated: May 1, 2026
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
Periapical tissue reaction to calcium phosphate root canal sealer in porcine model
George M Jacob1, Ajay Kumar, Jolly Mary Varughese
1Department of Conservative Dentistry and Endodontics, PSM College of Dental Science and Research, Akkikavu, Thrissur, Kerala, India.
Background:
Calcium phosphate cements (CPC) are a group of biomaterials possessing wide scope of use in various branches of medical science. These materials have been proposed to be highly biocompatible and osteoconductive. This study is based on a newly developed CPC formulation (Chitra-CPC) and is aimed at the evaluation of its biocompatibility through an Endodontic Usage Test in a porcine study model.
Objective:
To evaluate the periapical tissue reaction to Chitra-CPC when used as a root canal sealer/filler material in comparison with a resin sealer, AH Plus (Dentsply).
Materials And Methods:
The procedure was done on porcine animal model following the ISO 7405 criteria. The material was implanted intentionally into the periapical area of 36 teeth through a root canal procedure carried out in six animals which were divided equally among 1-month and 3-month time periods. Results were based on the histological evaluation of the autopsied specimens after the prescribed time periods.
Results:
Mild to moderate periapical tissue reaction was found in Chitra-CPC samples belonging to the 1-month time period, whereas majority of the 3-month CPC samples showed an absence of inflammation. Samples of AH Plus in 1-month period showed severe to moderate inflammation, whereas 3-month AH Plus samples had a mild to moderate inflammation.
Conclusions:
Chitra-CPC is a biocompatible material.
