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Author Spotlight: Investigating the Underlying Mechanisms of Right Ventricular Failure in Pulmonary Hypertension
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Idiopathic hemihypertrophy

Mabrook A Mohanna1, Abdul Khalig Sallam

  • 1Department of Pediatrics, Faculty of Medicine and Health Sciences, Sana'a University, PO Box 18660, Sana'a, Yemen. E-mail: mabrookmohanna@yahoo.com / draks601@yahoo.com.

Saudi Medical Journal
|April 22, 2014
PubMed

Insights

Idiopathic hemihypertrophy in Yemeni children is linked to a higher risk of embryonal tumors. This study highlights four cases in Sana

Area of Science:

  • Pediatric Oncology
  • Genetics
  • Developmental Biology

Background:

  • Idiopathic hemihypertrophy (IHH) is a rare congenital condition characterized by asymmetric overgrowth.
  • IHH is associated with an increased risk of embryonal tumors, necessitating vigilant monitoring.
  • Understanding IHH prevalence and associated conditions in diverse populations is crucial for early diagnosis and management.

Observation:

  • Four cases of IHH were identified in Yemeni children over three years in Sana'a.
  • Two cases presented with isolated hemihypertrophy.
  • Two cases exhibited hemihypertrophy alongside other significant medical conditions, including Wilms' tumor and ureteropelvic junction stricture with renal anomalies.

Findings:

  • The study identified left-sided hemihypertrophy in three cases and right-sided in one.
  • One case of left-sided hemihypertrophy was associated with Wilms' tumor.
  • Another case of right-sided hemihypertrophy presented with polydactyly, ureteropelvic junction stricture, hydronephrosis, and renal agenesis.

Implications:

  • This case series underscores the importance of recognizing hemihypertrophy as a potential indicator for embryonal tumors in pediatric populations.
  • Early detection and management of associated anomalies in children with hemihypertrophy can improve patient outcomes.
  • Further research is warranted to explore the genetic and environmental factors contributing to hemihypertrophy and its tumor predisposition in different ethnic groups.

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