Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Golden Jubilee of the International Association of Oral and Maxillofacial Pathologists (IAOP).

Oral surgery, oral medicine, oral pathology and oral radiology·2026

Same author

Development of Anemometer Based on Inertial Sensor.

Micromachines·2024

Same author

Hydrodynamic Evaluation of a Filtering Hydrocyclone for Solid Particle/Water Separation.

Membranes·2024

Same author

A Novel Design of a Torsional Shape Memory Alloy Actuator for Active Rudder.

Sensors (Basel, Switzerland)·2024

Same author

Agreement between Handheld and Standard Echocardiography for Diagnosis of Latent Rheumatic Heart Disease in Brazilian Schoolchildren from High-Prevalence Settings (Agreement between Screening and Standard Echo for RHD).

Diagnostics (Basel, Switzerland)·2024

Same author

Plaque-like cutaneous mucinosis in a patient with KRAS-mutated giant cell granuloma of the jaw.

International journal of dermatology·2024

Search research articles

Related Experiment Video

Updated: May 1, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Progress towards personalized medicine for ameloblastoma.

Carolina C Gomes, Marina G Diniz, Ricardo S Gomez

The Journal of Pathology

|April 22, 2014

Summary

Researchers discovered the BRAF V600E mutation in most ameloblastoma cases, identifying two distinct molecular pathways. This finding is crucial for developing targeted therapies for ameloblastoma, a destructive benign tumor.

Area of Science:

Oncology
Oral Pathology
Molecular Biology

Background:

Ameloblastoma is a locally infiltrative, benign odontogenic neoplasm known for its destructive potential and high recurrence rates.
Current treatment often involves radical surgery, leading to significant morbidity and facial deformity.
The molecular pathogenesis of ameloblastoma has remained largely unclear, hindering the development of targeted therapies.

Purpose of the Study:

To investigate the molecular drivers of ameloblastoma and identify potential therapeutic targets.
To understand the heterogeneity in response to targeted therapies observed in ameloblastoma cell cultures.
To advance the development of personalized medicine approaches for ameloblastoma treatment.

Main Methods:

Analysis of ameloblastoma primary cell cultures to assess response to EGFR-targeted therapy.

More Related Videos

Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts

Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts

Published on: May 25, 2018

Automating Tumor Implantation in Zebrafish Larvae for Cancer Research and Medicine

Automating Tumor Implantation in Zebrafish Larvae for Cancer Research and Medicine

Published on: September 19, 2025

Related Experiment Videos

Last Updated: May 1, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts

Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts

Published on: May 25, 2018

Automating Tumor Implantation in Zebrafish Larvae for Cancer Research and Medicine

Automating Tumor Implantation in Zebrafish Larvae for Cancer Research and Medicine

Published on: September 19, 2025

Genetic analysis of ameloblastoma samples to identify mutations.

Review of existing literature and discussion of findings in the context of tumor microenvironment and heterogeneity.

Main Results:

The oncogenic BRAF V600E mutation was identified in 63% of ameloblastoma samples.
Two distinct molecular pathways (EGFR and BRAF V600E) were defined in ameloblastoma pathogenesis.
Differential responses to EGFR-targeted therapy were observed, linked to the presence or absence of the BRAF mutation.

Conclusions:

The identification of BRAF V600E mutation and EGFR signaling provides distinct therapeutic targets for ameloblastoma.
These findings represent a significant step towards personalized medicine for ameloblastoma.
Tumor microenvironment and molecular heterogeneity must be considered for effective personalized therapy strategies.