Related Experiment Video
Updated: May 1, 2026
08:21
Sample Preparation in Quartz Crystal Microbalance Measurements of Protein Adsorption and Polymer Mechanics
Published on: January 22, 2020
13.0K
Progress of quartz crystal microbalance in chiral analysis
Journal of Nanoscience and Nanotechnology
|April 23, 2014
Summary
Chiral analysis, essential for distinguishing molecular configurations, is advancing with quartz crystal microbalance (QCM) sensors. This review covers QCM
Area of Science:
- Analytical Chemistry
- Sensor Technology
- Materials Science
Background:
- Chiral analysis is critical for differentiating subtle molecular configuration differences between isomers.
- Quartz crystal microbalance (QCM) offers high mass sensitivity, rapid response, online detection, and cost-effectiveness, making it promising for next-generation sensors.
- QCM has been a significant focus in chiral analysis research for the past two decades.
Purpose of the Study:
- To provide a comprehensive review of recent advancements in chiral analysis utilizing QCM detection.
- To highlight the various recognition elements employed in QCM-based chiral sensing.
- To discuss the future prospects of QCM technology in chiral analysis.
Main Methods:
- Review of scientific literature on QCM-based chiral analysis.
- Categorization of recognition elements used in QCM chiral sensors, including synthetic macromolecules, molecular imprinting polymers (MIPs), proteins, and amino acid derivatives.
- Analysis of QCM sensor performance characteristics relevant to chiral recognition.
Main Results:
- QCM sensors demonstrate significant potential for sensitive and selective chiral analysis.
- Diverse recognition elements, such as MIPs and biomolecules, have been successfully integrated with QCM for chiral detection.
- Recent advances show improved performance in terms of sensitivity, selectivity, and response time for QCM chiral sensors.
Conclusions:
- QCM is a powerful and versatile platform for developing advanced chiral analysis tools.
- The ongoing development of novel recognition elements will further enhance QCM capabilities for enantiomeric discrimination.
- QCM technology is poised for broader application in various fields requiring precise chiral analysis.
More Related Videos
Related Concept Videos
02:25Chirality
23.4K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
23.4K
02:30Chirality in Nature
13.5K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
13.5K
02:05Prochirality
4.0K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
4.0K
01:10Silica Gel Column Chromatography: Overview
3.9K
Silica gel column chromatography is a technique for separating compounds using a column packed with silica gel as the stationary phase. This method relies on differences in the polarity of compounds. Based on their polarities, compounds move between the stationary phase (silica gel) and the mobile phase (the solvent), forming discrete bands in the column.
Polar components tend to bind strongly to the silica gel, causing them to move slowly through the column. In contrast, nonpolar compounds...
Polar components tend to bind strongly to the silica gel, causing them to move slowly through the column. In contrast, nonpolar compounds...
3.9K