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ICSH: on board for new projects.

G Zini1, W Kern, M Brereton

  • 1Catholic University of Sacred Heart, Rome, Italy.

International Journal of Laboratory Hematology
|April 23, 2014
PubMed
Summary
This summary is machine-generated.

The International Council for Standardization in Hematology (ICSH) is advancing diagnostic accuracy through global harmonization of laboratory methods. Key projects focus on flow cytometry for leukemia diagnosis, standardizing reporting units, and ensuring reliable Hemoglobin A2 measurements.

Keywords:
ICSHflow cytometryhemoglobin A2units

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Area of Science:

  • Hematology
  • Clinical Chemistry
  • Laboratory Medicine

Background:

  • The International Council for Standardization in Hematology (ICSH) works to improve global quality and harmonization of analytical methods in diagnostic hematology.
  • Expert working groups examine laboratory methods and instruments, collaborating with international organizations to achieve reliable and reproducible results.

Purpose of the Study:

  • To present three selected ICSH projects focused on critical areas of hematological analysis and standardization.
  • To highlight advancements in flow cytometry for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) diagnosis.
  • To address variations in reporting units and Hemoglobin A2 measurements for improved clinical practice.

Main Methods:

  • Development of guidelines for multiparameter flow cytometry (MFC) in AML and MDS diagnosis, covering workflow integration, quality control, and interpretation.
  • Pilot studies to assess variations in routine blood cell count reporting units and identify areas for standardization.
  • Investigation into the standardization of Hemoglobin A2 measurement, including instrument assessment recommendations.

Main Results:

  • The flow cytometry project addresses comprehensive aspects of immunophenotyping for AML and MDS diagnosis.
  • Data indicates significant variation in hematology reporting units, necessitating standardization in nomenclature and units for cell counts and hemoglobin concentration.
  • Discrepancies in Hemoglobin A2 measurements across different instruments highlight the need for standardized assessment protocols.

Conclusions:

  • The presented ICSH projects exemplify a collaborative effort to enhance the reliability and reproducibility of diagnostic hematology worldwide.
  • Standardization in flow cytometry, reporting units, and HbA2 measurement is crucial for improving diagnostic accuracy and clinical decision-making.
  • ICSH provides a vital platform for global scientific collaboration and discussion in laboratory hematology.