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C-reactive protein and subclinical cardiovascular disease among African-Americans: (the Jackson Heart Study)

Jung Hye Sung1, Jae Eun Lee, Tandaw E Samdarshi

  • 1aSchool of Health Sciences bRTRN Data Coordinating Center, Jackson State University cUniversity of Mississippi School of Medicine, Jackson, Mississippi, USA.

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|April 23, 2014
PubMed

Insights

Systemic inflammation marker C-reactive protein (CRP) is linked to subclinical cardiovascular disease, specifically aortic valve calcification and peripheral arterial disease, in African-Americans.

Area of Science:

  • Cardiovascular Disease Research
  • Inflammation Biomarkers
  • Population Health Studies

Background:

  • Systemic inflammation is a potential early indicator of subclinical cardiovascular disease.
  • Previous research on inflammation and cardiovascular disease in African-Americans has yielded inconsistent findings.

Purpose of the Study:

  • To investigate the association between C-reactive protein (CRP) and subclinical cardiovascular disease in African-American adults.
  • To examine CRP's relationship with aortic valve calcification (AVC), carotid intima-medial thickness (IMT), and peripheral arterial disease (PAD).

Main Methods:

  • Analysis of data from African-American participants in the Jackson Heart Study.
  • Assessment of CRP levels in relation to AVC, carotid IMT, and PAD.
  • Statistical adjustments for various demographic, clinical, and lifestyle factors.

Main Results:

  • CRP showed a significant association with AVC (P=0.02) and PAD (P=0.04) in multivariable-adjusted models.
  • An association between CRP and carotid IMT was observed in age- and sex-adjusted models but not in multivariable models.
  • Prevalence of AVC was 5.1% and PAD was 6.7% in the study population.

Conclusions:

  • Significant associations were found between CRP and both AVC and PAD in a population-based cohort of African-Americans.
  • CRP may serve as a relevant biomarker for specific types of subclinical cardiovascular disease in this demographic.
Abstract

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