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Updated: Apr 30, 2026

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
Published on: June 21, 2024
The use of aprepitant in a case of refractory nausea and vomiting
Lucy Lowery1, Inga Andrew1, Sarah Gill1
1St Benedict's Hospice, Sunderland, UK.
Background:
This case report describes a patient whose refractory nausea and vomiting significantly improved with the use of aprepitant, a neurokinin receptor antagonist currently only licensed for short-term use in chemotherapy-induced nausea and vomiting.
Case Presentation:
A patient with breast cancer and meningeal metastases had an 18-month history of nausea and vomiting refractory to a number of antiemetics commonly used in palliative care. The nausea and vomiting resolved after receiving two doses of the drug aprepitant.
Case Management And Outcome:
Maintenance antiemetic treatment with aprepitant was continued over a 5-month period with no recurrence of nausea and vomiting, and no observed side effects.
Conclusions:
Aprepitant has a potential role as an antiemetic for refractory symptoms within the palliative-care setting.
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