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Related Experiment Video

Updated: Apr 30, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

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TRPM4.

Ilka Mathar1, Griet Jacobs, Miklos Kecskes

  • 1Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Herestraat 49, bus 802, 3000, Leuven, Belgium.

Handbook of Experimental Pharmacology
|April 24, 2014
PubMed
Summary

Transient Receptor Potential Melastatin 4 (TRPM4) channels are Ca(2+)-activated, allowing Na(+) influx. This review details TRPM4

Area of Science:

  • Molecular Biology
  • Cell Physiology
  • Ion Channel Function

Background:

  • Transient Receptor Potential Melastatin 4 (TRPM4) is a Ca(2+)-activated nonselective cation channel.
  • TRPM4 is activated by intracellular Ca(2+) and regulated by temperature and phosphoinositides.
  • TRPM4 channels are widely expressed, unlike their closest relative TRPM5.

Purpose of the Study:

  • To review the functional properties of TRPM4.
  • To summarize the current understanding of TRPM4's physiological role in health and disease.

Main Methods:

  • Literature review of functional properties.
  • Analysis of data from knockout mouse models.
  • Examination of human genetic studies linking TRPM4 mutations to disease.

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Main Results:

  • TRPM4 facilitates Na(+) entry but not Ca(2+) entry.
  • TRPM4's physiological roles are increasingly understood through knockout models.
  • TRPM4 gene mutations are linked to cardiac conduction disorders.

Conclusions:

  • TRPM4 plays a significant role in various tissues.
  • Further research is needed to fully elucidate TRPM4's physiological and pathophysiological functions.