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Related Concept Videos

Thermosensation01:43

Thermosensation

29.7K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Repressible Operon: trp Operon01:21

Repressible Operon: trp Operon

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The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...
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Cotranslational Protein Translocation01:20

Cotranslational Protein Translocation

8.3K
Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
Sec61 channel partners for cotranslational translocation
During cotranslational translocation, the Sec61 channel partners with the signal recognition particle (SRP), the signal recognition particle receptor (SR), and the ribosomes to transport the nascent polypeptide chain...
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LTR Retrotransposons03:08

LTR Retrotransposons

18.1K
LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
18.1K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

64.6K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
64.6K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

12.4K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Articles linked to this work by shared authors, journal, and citation graph.

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Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function.

Nature communications·2022
Same author

The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain.

Nature communications·2022
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Paracetamol analogues conjugated by FAAH induce TRPV1-mediated antinociception without causing acute liver toxicity.

European journal of medicinal chemistry·2020
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Electrophile-Induced Conformational Switch of the Human TRPA1 Ion Channel Detected by Mass Spectrometry.

International journal of molecular sciences·2020
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Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel.

Cell calcium·2020
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Calcium activates purified human TRPA1 with and without its N-terminal ankyrin repeat domain in the absence of calmodulin.

Cell calcium·2020

Related Experiment Video

Updated: Apr 30, 2026

Cell-based Calcium Assay for Medium to High Throughput Screening of TRP Channel Functions using FlexStation 3
07:26

Cell-based Calcium Assay for Medium to High Throughput Screening of TRP Channel Functions using FlexStation 3

Published on: August 17, 2011

20.8K

TRPA1.

Peter M Zygmunt1, Edward D Högestätt

  • 1Clinical and Experimental Pharmacology, Clinical Chemistry, Department of Laboratory Medicine, Lund University, Skåne University Hospital, SE-221 85, Lund, Sweden, peter.zygmunt@med.lu.se.

Handbook of Experimental Pharmacology
|April 24, 2014
PubMed
Summary

The transient receptor potential ankyrin subtype 1 (TRPA1) channel detects noxious stimuli and is involved in pain and itch. Non-electrophilic compounds like menthol activate TRPA1, offering potential for new pain relief therapies.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • The transient receptor potential ankyrin subtype 1 (TRPA1) protein functions as a nonselective cation channel.
  • TRPA1 is implicated in nociception, including chemical, cold, and mechanical sensations.
  • It is expressed in sensory neurons and epithelial cells.

Purpose of the Study:

  • To explore the activation mechanisms of the TRPA1 channel.
  • To investigate the potential of TRPA1 as a drug target for pain, itch, and sensory hyperreactivity.

Main Methods:

  • The study reviews TRPA1 activation by electrophiles, oxidants, and pro-inflammatory agents via the phospholipase C pathway.
  • It examines activation by non-electrophilic compounds such as menthol and cannabinoids.

More Related Videos

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

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Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
11:21

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

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Related Experiment Videos

Last Updated: Apr 30, 2026

Cell-based Calcium Assay for Medium to High Throughput Screening of TRP Channel Functions using FlexStation 3
07:26

Cell-based Calcium Assay for Medium to High Throughput Screening of TRP Channel Functions using FlexStation 3

Published on: August 17, 2011

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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

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Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs
11:21

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

Published on: September 10, 2017

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Main Results:

  • TRPA1 is activated by a diverse range of chemical and physical stimuli.
  • Non-electrophilic compounds can activate TRPA1, suggesting potential for targeted drug design.
  • Endogenous ligands may also regulate TRPA1 activity.

Conclusions:

  • TRPA1 is a key player in sensory perception and a promising therapeutic target.
  • Developing non-tissue damaging TRPA1 activators could lead to novel treatments for pain and related disorders.