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Bolus tracking with nanofilter-based multispectral videography for capturing microvasculature hemodynamics
Mohamadreza Najiminaini1, Bozena Kaminska2, Keith St Lawrence3
11] Imaging Program, Lawson Health Research Institute, St. Joseph's Health Care, London, ON, Canada [2] The School of Engineering Science, Simon Fraser University, Burnaby, BC, Canada [3] Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
We developed nanofilter-based multispectral videography (nMSV) for detailed microvasculature analysis. This new imaging technique can reveal tissue hemodynamics, aiding in conditions like skin cancer detection.
Area of Science:
- Biomedical Imaging
- Materials Science
- Optical Engineering
Background:
- Multispectral imaging is crucial for analyzing materials in fields like food production, satellite reconnaissance, and biomedical imaging.
- Existing methods often lack the resolution or specificity required for detailed microvascular analysis.
Purpose of the Study:
- To introduce nanofilter-based multispectral videography (nMSV) for high-resolution imaging of microvasculature.
- To demonstrate the capability of nMSV in analyzing tissue hemodynamics.
- To explore potential applications in disease detection, such as skin cancer.
Main Methods:
- Utilized 3D metallic nanostructures with tunable extraordinary optical transmission properties.
- Developed nMSV operating in the 700 to 950 nm spectral range.
- Acquired spectral videos of piglet ear microvasculature following an intravascular tracer injection.
Main Results:
- nMSV successfully generated spectral videos of microvasculature.
- Analysis revealed contrast measurements indicative of arterial pulsation and microvascular transit times.
- Demonstrated effective separation of arterial and venous signals within the tissue.
Conclusions:
- nMSV is a novel technique capable of acquiring serial multispectral images relevant to tissue hemodynamics.
- The technology shows promise for applications in detecting and identifying skin cancer.
- Further research can explore broader biomedical and material analysis applications.
