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Evaluation of three embolic agents in pig rete
D H Lee1, C H Wriedt, J C Kaufmann
1Department of Diagnostic Radiology, University Hospital, University of Western Ontario, London, Canada.
AJNR. American Journal of Neuroradiology
|July 1, 1989
Summary
Microfibrillar collagen hemostat in ethanol shows promise as an embolic agent for low-flow structures. Other agents like Angiostat and Tisseel were less effective or caused adverse effects in pig rete occlusion studies.
Area of Science:
- Biomedical Engineering
- Interventional Radiology
- Vascular Surgery
Background:
- Embolic agents are crucial for minimally invasive vascular procedures.
- Identifying effective and safe agents for low-flow structures remains a challenge.
Purpose of the Study:
- To evaluate the efficacy and safety of three potential embolic agents for pig rete occlusion.
- To determine the most suitable agent for therapeutic embolization in low-flow vascular environments.
Main Methods:
- Selective injection of three agents into the pig rete: microfibrillar collagen hemostat in 33% ethanol, Angiostat (collagen particulate), and Tisseel (tissue sealant).
- Assessment of occlusion effectiveness and observation for adverse effects in the animal model.
Main Results:
- Microfibrillar collagen hemostat in ethanol demonstrated the most effective rete occlusion.
- Angiostat failed to occlude the rete and led to severe adverse effects, including coma and apnea.
- Tisseel achieved partial occlusion but presented management difficulties with long catheters, leading to its discontinuation.
Conclusions:
- Microfibrillar collagen hemostat in ethanol exhibits significant potential as an embolic agent for low-flow vascular structures.
- Angiostat and Tisseel are not suitable for this application due to ineffectiveness or safety concerns.