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Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
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Cerebral microvascular lesions on high-resolution 7-Tesla MRI in patients with type 2 diabetes

Manon Brundel1, Yael D Reijmer2, Susanne J van Veluw2

  • 1Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands m.brundel-2@umcutrecht.nl.

Diabetes
|April 25, 2014
PubMed

Insights

Microvascular brain lesions, like microinfarcts, are not more common in type 2 diabetes mellitus patients than controls. These lesions did not correlate with cognitive deficits in this ultra-high field MRI study.

Area of Science:

  • Neurology
  • Radiology
  • Endocrinology

Background:

  • Cerebral small vessel disease and microvascular lesions are implicated in type 2 diabetes mellitus (T2DM)-associated cognitive deficits.
  • Ultra-high field MRI enables in vivo visualization of microvascular lesions such as microinfarcts and microbleeds.

Purpose of the Study:

  • To investigate the prevalence of microvascular brain lesions in non-demented older individuals with T2DM compared to controls.
  • To determine the association between microvascular lesions and cognitive performance in T2DM patients.

Main Methods:

  • Utilized 7-Tesla MRI to assess cortical microinfarcts and cerebral microbleeds in 48 T2DM patients and 49 controls.
  • Compared lesion occurrence between groups and correlated with detailed cognitive assessment results.

Main Results:

  • Microinfarcts were found in 48% of T2DM patients and 38% of controls; microbleeds in 33% of T2DM patients and 41% of controls (P > 0.05 for both).
  • The presence and number of microinfarcts or microbleeds were not significantly related to cognitive performance.

Conclusions:

  • Microvascular brain lesions visualized by ultra-high field MRI are not significantly more prevalent in well-controlled T2DM patients compared to age- and sex-matched controls.
  • Findings suggest microvascular lesions may not be a primary driver of cognitive deficits in this T2DM cohort.

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