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Protein stabilization by blocking the native unfolding nucleus
1Department of Biotechnology, Martin-Luther University, Halle, GDR.
Biomedica Biochimica Acta
|January 1, 1989
Abstract:
Studies on the thermal inactivation of immobilized enzymes result in a novel conception of protein stabilization. The native protein molecule is suggested to be characterized by a specific structural region where the unfolding process starts. Accordingly, enzyme stabilization by immobilization is the result of blocking this unfolding nucleus.