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[Comparative study of antitumor activity of cantharidin and cantharis peptides]
Objective:
To prepare cantharidin and cantharidin peptides from Mylabris and compare their antitumor activity.
Methods:
Cantharis peptides was prepared by bionic enzymolysis approach and cantharidin was prepared by alkaline water supersonic extraction. The inhibitory effects of both compounds on BEL-7402 cells proliferation of human liver cancer were tested by Prestoblue method. The influence of both compounds on the grown of tumor, thymus, spleen of S180 tumor-bearing mice were detected.
Results:
Cantharis peptides and cantharidin could inhibit the proliferation of BEL-7402 cells (P < 0.05) in vivo, and the inhibitory effect of cantharis peptide was 12.54% lower than that of cantharidin. At the same time, they could inhibit the grown of S180 sarcoma (P < 0.05), and the inhibitory effect of cantharidin was higher than that of cantharis peptides (5.93%). Furthermore, cantharis peptides could't inhibit the grown of thymus and spleen.
Conclusion:
Both cantharis peptides and cantharidin have antineoplastic activity, but cantharidin peptides have no immunosuppression.
