Related Experiment Video
Updated: Apr 30, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
Intestinal microbiota: unexpected alliance with tumor therapy
1Division of Molecular Bioregualtion, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan.
Abstract:
Evaluation of: Iida N, Dzutsev A, Stewart CA et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science 342, 967-970 (2013). Intestinal microbiota is essential for host physiological processes, including the maintenance of epithelial barrier and immune functions. However, paradoxically, the intestinal microbiota can promote various types of experimental carcinogenesis. The paper under evaluation demonstrates that disruption of the microbiota impairs the response of tumors to CpG-oligonucleotide immunotherapy and platinum chemotherapy in a context-dependent manner. Thus, intestinal microbiota may have a great impact on the tumor response to chemotherapy and/or immunotherapy.
More Related Videos
Related Concept Videos
Introduction to the Human Microbiota
Microbiota of the Stomach and Small Intestine
The Tumor Microenvironment
The Tumor Microenvironment
Functions of the Gut Microbiota
Microbiota of the Large Intestine

