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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Related Experiment Video

Updated: Apr 30, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
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Inflammation, ageing and chronic disease.

Graham Pawelec1, David Goldeck1, Evelyna Derhovanessian1

  • 1Tübingen Ageing and Tumour Immunology Group, Second Department of Internal Medicine, Center for Medical Research, ZMF, Waldhörnlerstr. 22, D-72072 Tübingen, Germany.

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Inflammation is vital for healing but chronic inflammation in aging is linked to diseases. This review examines recent research on inflammation and age-related chronic conditions.

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Area of Science:

  • Immunology
  • Gerontology
  • Pathology

Background:

  • Acute inflammation is crucial for host defense and tissue repair.
  • However, dysregulated or chronic inflammation contributes to age-associated diseases.
  • Low-grade systemic inflammation is common in elderly individuals.

Purpose of the Study:

  • To review recent (past two years) literature on the interplay between inflammatory status and chronic diseases of aging.
  • To synthesize new data on the detrimental effects of chronic inflammation in the elderly.

Main Methods:

  • Systematic literature review of studies published in the last two years.
  • Analysis of research focusing on inflammation markers and age-related diseases.

Main Results:

  • Recent studies highlight significant links between chronic inflammation and various age-related diseases.
  • Evidence suggests inflammation may be a causal factor in some chronic conditions of aging.
  • Age-associated immune dysregulation exacerbates detrimental inflammatory effects.

Conclusions:

  • Chronic, low-level systemic inflammation is a key factor in the pathogenesis of many age-related diseases.
  • Understanding these inter-relationships is crucial for developing interventions to mitigate disease in aging populations.
  • Further research is needed to elucidate the precise mechanisms linking inflammation and aging.