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Nrf2 negatively regulates melanogenesis by modulating PI3K/Akt signaling

Jung-Min Shin1, Mi Yoon Kim1, Kyung-Cheol Sohn1

  • 1Department of Dermatology and Research Institute for Medical Sciences, School of Medicine, Chungnam National University, Daejeon, Korea.

Plos One
|April 26, 2014
PubMed
Summary

Nuclear factor erythroid 2-related factor 2 (Nrf2) inhibits melanogenesis, the process of melanin production. Nrf2 activation decreases melanin synthesis and key enzyme expression in human melanocytes via the PI3K/Akt pathway.

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