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Increased Serum Cold-Inducible RNA-Binding Protein Levels in Psoriasis.
Jung-Min Shin1, Jung Eun Kim2, Dongkyun Hong1
1Department of Dermatology, Chungnam National University Hospital, School of Medicine, Chungnam National University, Daejeon, Korea.
Annals of Dermatology
|April 6, 2026
Summary
Elevated levels of cold-inducible RNA-binding protein (CIRP) were found in psoriasis patients, suggesting its role in the disease's immune mechanisms. This finding highlights CIRP as a potential therapeutic target for psoriasis.
Area of Science:
- Immunodermatology
- Molecular biology
- Stress response mechanisms
Background:
- Psoriasis is a chronic inflammatory skin condition characterized by erythematous plaques and scales.
- The precise molecular triggers of psoriasis, an immune-driven disease, are not fully understood.
- Cold-inducible RNA-binding protein (CIRP) is a stress-response protein identified as a damage-associated molecular pattern that can activate immune responses.
Purpose of the Study:
- To investigate the association between serum levels of CIRP and the clinical and histological features of psoriasis.
- To explore CIRP as a potential biomarker and therapeutic target in psoriasis.
Main Methods:
- Serum CIRP concentrations were measured in 67 psoriasis patients and 20 healthy controls.
- Correlations between CIRP levels and clinical/histological indices of psoriasis were analyzed.
Main Results:
- Psoriasis patients demonstrated significantly higher serum CIRP levels than healthy controls.
- While CIRP showed correlations with some clinical and histological indicators, it did not significantly correlate with disease severity (PASSI score), joint involvement, or nail changes.
Conclusions:
- The study supports the involvement of CIRP in the immunopathogenesis of psoriasis.
- CIRP emerges as a potential therapeutic target for modulating psoriasis.
