Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

1.1K
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
1.1K
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

1.5K
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
1.5K
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

7.2K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
7.2K
Analgesia and Pain Management01:25

Analgesia and Pain Management

3.3K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
3.3K
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

7.2K
A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
7.2K
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

10.2K
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Notes on the History of In Vitro Hippocampal Electrophysiology and LTP: Personal Reflections.

Hippocampus·2025
Same author

Neuroscience Needs to Test Both Statistical and Scientific Hypotheses.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2022
Same author

Scientific Hypothesis-Testing Strengthens Neuroscience Research.

eNeuro·2020
Same author

David Casarett's Stoned: A Doctor's Case for Medical Marijuana.

Cerebrum : the Dana forum on brain science·2016
Same author

Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy.

Nature reviews. Neuroscience·2015
Same author

Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2015
Same journal

A Perfect Storm.

Cerebrum : the Dana forum on brain science·2022
Same journal

Managing Pain.

Cerebrum : the Dana forum on brain science·2022
Same journal

Imaging's Groundbreaking Discovery: 30 Years Later.

Cerebrum : the Dana forum on brain science·2022
Same journal

Poverty and Developing Brain.

Cerebrum : the Dana forum on brain science·2022
Same journal

Interoception: The Secret Ingredient.

Cerebrum : the Dana forum on brain science·2021
Same journal

His and Hers: Sex Differences in the Brain.

Cerebrum : the Dana forum on brain science·2021
See all related articles

Related Experiment Video

Updated: Apr 30, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

1.3K

Getting high on the endocannabinoid system.

Bradley E Alger

    Cerebrum : the Dana Forum on Brain Science
    |April 26, 2014
    PubMed
    Summary
    This summary is machine-generated.

    The endogenous cannabinoid system plays a crucial role in maintaining human health. Understanding this system reveals how brain activity connects to physical health and disease states.

    More Related Videos

    Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
    03:43

    Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

    Published on: August 22, 2025

    769
    Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
    05:13

    Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

    Published on: February 28, 2025

    813

    Related Experiment Videos

    Last Updated: Apr 30, 2026

    Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
    07:51

    Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

    Published on: August 1, 2025

    1.3K
    Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
    03:43

    Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

    Published on: August 22, 2025

    769
    Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
    05:13

    Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes

    Published on: February 28, 2025

    813

    Area of Science:

    • Physiology
    • Neuroscience
    • Immunology

    Background:

    • The endocannabinoid system is vital for human health.
    • Endocannabinoids and their receptors are distributed throughout the body, including the brain, organs, and immune cells.
    • This system acts as a bridge between the body and mind.

    Purpose of the Study:

    • To highlight the physiological significance of the endogenous cannabinoid system.
    • To explain the widespread presence and function of endocannabinoids.
    • To underscore the system's role in connecting mental and physical health.

    Main Methods:

    • Literature review of cannabinoid system research.
    • Analysis of the physiological distribution of endocannabinoids and receptors.
    • Synthesis of current understanding of endocannabinoid functions.

    Main Results:

    • The endogenous cannabinoid system is integral to maintaining homeostasis.
    • Cannabinoid receptors are present in key tissues, influencing various bodily functions.
    • The system demonstrates complex interactions across the immune, nervous, and organ systems.

    Conclusions:

    • The endogenous cannabinoid system is a fundamental physiological network.
    • Understanding this system provides insight into the mind-body connection.
    • Further research into the endocannabinoid system could illuminate mechanisms underlying health and disease.