Related Experiment Video
Updated: Feb 14, 2026
08:31
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
714
Acute promyelocytic leukemia, hypogranular variant: a rare presentation
Kafil Akhtar1, Shamshad Ahmad1, Rana K Sherwani1
1Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh (UP)-India.
Clinics and Practice
|April 26, 2014
Summary
Early diagnosis of acute promyelocytic leukemia (APL) is crucial due to bleeding risks and ATRA treatment response. This summary highlights a rare hypogranular APL variant that presents diagnostic difficulties.
Area of Science:
- Hematology
- Oncology
- Cell Biology
Background:
- Acute promyelocytic leukemia (APL) requires prompt diagnosis for effective management.
- Life-threatening coagulopathy is a significant complication of APL.
- All-trans retinoic acid (ATRA) is a key therapeutic agent for APL.
Purpose of the Study:
- To report a rare case of the hypogranular variant of APL.
- To discuss the diagnostic challenges associated with this APL subtype.
Main Methods:
- Review of a specific patient case.
- Analysis of characteristic cell morphology.
- Application of cytochemical staining techniques.
Main Results:
- The case presented a diagnostic challenge.
- Morphological and cytochemical findings were evaluated.
Conclusions:
- The hypogranular variant of APL can be difficult to diagnose.
- Characteristic morphology and cytochemistry are vital for rapid APL diagnosis.
Related Concept Videos
01:25Self-Presentation
327
Self-presentation is a fundamental aspect of social interaction, shaping both how others perceive individuals and how they view themselves. This dynamic process influences behaviors in various social settings, often leading people to adjust their appearance, speech, and demeanor to align with their desired identity. While self-presentation can be deliberate or unconscious, it plays a critical role in interpersonal relationships and self-perception.Forms of Self-PresentationSelf-presentation can...
327
01:12Strategies of Self-Presentation I: Strategic Self-Presentation
230
Strategic self-presentation refers to individuals' intentional efforts to influence how others perceive them. This process is employed in various social and professional settings, such as job interviews, dating, politics, and legal contexts, where individuals seek to shape impressions to gain social or material advantages. While people generally present themselves in ways that align with their authentic characteristics, external factors, such as cognitive load, can hinder their ability to...
230
01:29Processes of Self-Presentation
257
Effective self-presentation is a central component of social interaction and identity construction. It relies on the dynamic processes of defining the situation and engaging in self-disclosure. These mechanisms help individuals navigate social context expectations and manage how others perceive them, fostering mutual understanding and relationship development.Defining the SituationSocial situations are shaped by collectively understood frames—a set of widely understood rules or...
257
01:17Strategies of Self-Presentation II: Self-Verification
208
Self-verification is a fundamental psychological drive wherein individuals seek affirmation of their self-concept from others, striving for consistency between their internal self-view and external perceptions. This drive operates even when the self-concept is negative, influencing interpersonal behavior and feedback preferences in complex and often counterintuitive ways. Unlike the self-enhancement motive, which seeks positive evaluations, self-verification prioritizes coherence and...
208
02:05Self-Presentation: Self-Monitoring and Self-Handicapping
44.8K
People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
44.8K
02:30Histone Variants at the Centromere
5.1K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.1K