A concise colorimetric and fluorimetric probe for sarin related threats designed via the "covalent-assembly" approach
1State Key Laboratory of Bioreactor Engineering, ‡Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
Abstract:
A turn-on signal from zero background allows sensitive detection of a weak signal and is highly desired. The "covalent-assembly" probe design principle is powerful in this regard. Herein, we report an embodiment of this principle (NA570) for detection of Sarin related threats, based on a phenylogous Vilsmeier-Haack reaction. NA570 bears a concise molecular construct, exhibits a colorimetric and a fluorimetric signal, and has potential for real applications.
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